The Pediatric Surgical Research Laboratories at the Children's Hospital of New York-Presbyterian focus on the investigation of diseases of childhood.
On the Columbia campus, Dr. Jessica Kandel co-directs the Pediatric Tumor Biology Laboratory in conjunction with Dr. Darrell Yamashiro. Dr. Kandel's group investigates how new blood vessels develop in and supply growing tumors, focusing on common solid tumors of childhood (neuroblastoma, Wilms tumor, and hepatoblastoma).
Drs. Kandel and Yamashiro were the first to describe the anti-tumor effect of blocking blood vessel growth in models of these tumors, by antagonizing a factor that encourages blood vessel cells to multiply and form new vascular networks. This work is described in a number of publications (see links to recent papers, below), and has led to proposals for a national trial of this new kind of therapy for children with resistant cancers.
- Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma. Kim ES, Serur A, Huang J, Manley CA, McCrudden KW, Frischer JS, Soffer SZ, Ring L, New T, Zabski S, Rudge JS, Holash J, Yancopoulos GD, Kandel JJ, Yamashiro DJ.
- Topotecan is anti-angiogenic in experimental hepatoblastoma. McCrudden KW, Yokoi A, Thosani A, Soffer SZ, Kim ES, Huang J, Manley C, O'toole K, Yamashiro DJ, Kandel JJ, Middlesworth W.
- Resistance of a VEGF-producing tumor to anti-VEGF antibody: unimpeded growth of human rhabdoid tumor xenografts. Soffer SZ, Kim E, Huang J, McCrudden K, Yokoi A, Moore JT, Manley C, O'Toole K, Middlesworth W, Stolar C, Yamashiro DJ, Kandel JJ.
- p53 accumulation in favorable-histology Wilms tumor is associated angiogenesis and clinically aggressive disease. Huang J, Soffer SZ, Kim ES, Yokoi A, Moore JT, McCrudden KW, Manley C, Middlesworth W, O'Toole K, Stolar C, Yamashiro DJ, Kandel JJ.
On the Cornell campus, Dr. Terry Buchmiller Crair directs the Pediatric Surgical Laboratory with a focus on fetal gastrointestinal development. Additionally, Dr. Buchmiller Crair's group is studying how manipulation of the amniotic fluid environment can benefit the developing fetus, especially those afflicted with intrauterine growth retardation. This work has been described in a number of publications that are listed with their links below.
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